This guidance is for staff and managers working in adult social care settings (ASC). It gives information on multidrug-resistant organisms and principles on how to prevent the spread of these pathogens.
Main messages
- multidrug-resistant organisms (MDROs) are pathogens that do not respond to common treatments such as antibiotics, antivirals, antifungals and antiparasitics, making them difficult to treat
- MDROs spread through direct contact (including care activities) and indirect contact (for example, contaminated surfaces or equipment)
- individuals at higher risk of infection include those with wounds, medical devices, or weakened immunity. Carriage without symptoms is common, not harmful, and can last years
- it is usually safe to admit or readmit someone with current or previous MDRO carriage. Good infection prevention and control (IPC) practices will lower the chance of spread
- main contributors to spread include poor hand hygiene, contaminated environments, and unclean equipment
- it is important to balance safety with dignity, autonomy, and inclusion for individuals carrying MDROs
Summary of recommendations
- clean hands before and after contact with individuals with a MDRO using soap and water or alcohol-based hand rub
- support individuals with a MDRO to clean their hands frequently and remind visitors to clean their hands too
- promote good respiratory hygiene and improve ventilation when respiratory infections are suspected or confirmed
- use personal protective equipment (PPE) such as gloves, aprons, masks, and eye protection if there is a risk of blood or body fluid exposure
- clean the environment daily, focusing on high-touch areas
- disinfect shared equipment before and after use
- clean and dirty linen should be kept separate at all times
- wash infectious linen at high temperatures
- follow standard waste disposal procedures unless advised otherwise
- accommodate individuals with an MDRO in single rooms with ensuite if possible
- let healthcare staff know about MDRO carriage during admission or transfer
Read the full guidance here.


